Next-GEN CTC

Next generation Circulating Tumor Cell
capture and analysis
Convenient
48 Hr Processing
High
Capture Yields
IHC, FISH
7 Channel
Multiplex
High Resolution
Image Analysis
Cost Effective

The Next-GEN ctc advantage

next-gen ctc in action:
liquid biopsy diagnostics tests

oncostat

next-gen ctc in action:
liquid biopsy diagnostics tests

CTC
Enumeration

Oncostat COUNT is a high yield epithelial CTC and enumeration diagnostics test. CTC enumeration can be used to identify tumor recurrence and monitor disease progression.

Tumor
PD-L1

Oncostat PDL1 is a high yield epithelial CTC capture and cell membrane PD-L1 characterization diagnostics test. Tumor PD-L1 can be used to determine potential efficacy of PD1/PD-L1 therapies.

Click here for a summary of the Oncostat protocol

pipeline

upcoming oncostat
liquid biopsy diagnostics tests

Tumor
LYNCH syndrome

Oncostat TLS is a high yield epithelial CTC capture and tumor Lynch Syndrome characterization diagnostics test using MLH1, PMS2, MSH2 and MSH6 protein staining on CTCs

NTRK IHC
Screener

Oncostat NTRK-I is a high yield epithelial CTC capture and NTRK gene fusion screener using pan-TRK antibodies to detect TRKA, TRKB, and TRKC proteins on CTCs

NTRK FISH

Oncostat NTRK-F is a high yield epithelial CTC capture and NTRK1, NTRK2, and NTRK3 characterization diagnostics test using multiplexed FISH probes and high resolution imaging

PD-L1 +
tumor burden

Oncostat PDL1+ is a high yield epithelial CTC capture and membrane PD-L1 characterization diagnostics test plus tumor burden scoring. Tumor burden scores are calculated using image texture analysis of CTC nuclei.

AR-V7

Oncostat ARV7 is a high yield epithelial CTC capture and AR-V7 characterization diagnostics test. It can help guide therapy for patients with metastatic castration resistant prostate cancer.

Technology

specialized nanobeads
At the heart of Next-Gen CTC is a unique set of specialized beads each one optimized for a specific task: labeling, enrichment, and manipulation for imaging.

Cytotag
nanobeads

Optimized to label small cells and cell with very low antigen receptor density

- Non-crystalline, smooth core minimizes non-specific binding
- Uniform nano size with low mass and extraordinarily high diffusion
- Non-magnetic core has a specific density similar to nucleated cells optimizing labeling efficiency
- Covalently coupled to an antibody of choice (EpCAM or others) and to a linker highly specific to the Cytopull nanobeads

CytoPULL
nanobeads

Optimized to bind to Cytotag nanobeads and create high magnetic loads on tagged CTCs

- Uniform paramagnetic beads
- Nanosized to improve particle diffusion
- Capability to bind to each other to create aggregates with enough magnetic load to enrich CTCs from a tube of whole blood
- Extremelly low non-specific binding

cytohandle
nanobeads

Optimized to manipulate enriched CTC samples for low resolution imaging

- Uniformly sized paramagnetic beads used to manipulate cells
- Non-aggregating which prevents potential clustering that impedes visualization
- Druning imaging, they allow for fast focusing of cells on wall of optical cuvettes using a custom magnetic holder

next-gen CTC optimization

celldispenser

Instrument designed to deliver small absolute numbers of unlabeled cells

- Using the Coulter principle and precise microfluidics, the CellDispenser delivers exact absolute counts of cells from a cell suspension to microtubes
- Used to prepare controls from cell lines
- Automated and fast

cytorinse

Proprietary filter designed to remove excess label from small and highly enriched cell samples with zero cell loss

- Removes excess nanobeads and reagents from sample
- No-clog design
- Exceptionally gentle to protect cell morphology
- Fast

contact us to learn about our custom research lab services: extensive capabilities and ultra-fast turnaround times